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Even though no significant discrepancies were present in tyrosine hydroxylase exercise and expression, brain tissue amounts of 3,four-dihydroxyphenylalanine were being threefold increased in α2A- and α2C-adrenoceptor KO mice. Brain tissue levels of dopamine and noradrenaline were significantly increased in α2A and α2CKOs compared with WT [WT: 2